New research confirms it’s critical to talk about differences in treating men’s hearts vs. women’s hearts
Regular readers of this blog know I believe that promoting women’s-heart-care expertise can be a strong competitive advantage.
Here’s more evidence.
According to a new study:
- More women with aortic valve (AV) stenosis tended to exhibit left ventricular (LV) hypertrophy than men;
- But women also reversed the hypertrophy faster immediately following valve replacement surgery;
- And genetic differences affecting fibrosis may be responsible for this phenomenon.
Investigators at University of Berlin assessed 92 patients — 53 women with an average age of 72, and 39 men with an average age of 67 — undergoing AV replacement LV hypertrophy and its post-op regression.
After AV replacement, the prevalence of LV hypertrophy decreased in women at a greater rate than in men: 86 to 45 percent versus 56 to 36 percent.
- Men exhibited a greater makeup of collagen and metalloproteinase (MMP), which were “well in agreement with higher levels of fibrous tissues in the hearts of men compared to women,” and only men showed an increase in fibrous tissue gene expression.
- The researchers noted that while other studies reported sex differences in collagen architecture, little research has been performed regarding molecular analysis like those done in this study.
Study co-author Vera Regitz-Zagrosek, MD, concluded: “It is important to study gender differences in elderly patients. Many think that when people don’t have sex hormones or have low levels, women and men are the same. This is untrue. To develop optimal treatment for both, we need studies that pre-specify gender differences as an endpoint and that have enough statistical power to look at the differences between women and men.”
I would venture to say that few patients would have a full understanding of this study’s details. However, I’m equally sure that knowing their physicians do understand these details could be a significant factor in patient acquisition and satisfaction.